Higher Vision Cannabis ( @Higher Vision Cannabis
) has his #dose
Repost from @hightimesmagazine's article: 'The Next Frontier: Designing Your High', excerpted from 'Brave New Weed: Adventures into the Uncharted World of Cannabis' by Joe Dolce -
Dose is one of the few ways that cannabis mirrors alcohol. One or two drinks can act as a social lubricant; five can make you socially disconnected. Aspirin is another example. At 600 milligrams, aspirin reduces pain and inflammation. At 100 to 160 milligrams, it unclogs arteries.3 The relationship between dose and effect wasn’t firmly established until Dr. Mark Wallace at the University of California, San Diego, injected capsaicin, the ingredient in chili pepper that burns, into the arms of volunteers and then treated them with varying doses of cannabis. At too low of a dose, subjects got no pain relief. A moderate dose provided excellent relief, but too high of a dose actually magnified the pain. The conclusion? Cannabis is so dose specific that large and small amounts create opposite effects. “Because it’s nontoxic there’s been no guidance and that’s a problem,” says Backes. “With tequila, someone might say, ‘Don’t drink five shots or you’ll be unhappy.’ No one says that with pot. They think that once you reach a certain level of psychoactivity you’ll automatically know when to stop. You won’t. “A lot of people say they stopped smoking at some point because it made them paranoid. What’s making them paranoid is an overdose of THC. Reduce that and it goes away. It took me a year to figure out to smoke a match head instead of a bowl.” Binge smoking or oversmoking is yet another unforeseen result of prohibition, he contends, just as binge drinking became the norm in the 1920s and ’30s, when drinkers would stockpile and guzzle as much grain alcohol as they could because they never knew where their next batch was coming from.
The second key to taming today’s pot is understanding the role that the lost molecule, CBD, plays in modulating the high. Without it, aficionados claim the plant has morphed from something that produces a complex and subtle enhancement—think wine—to a powerful fuel, like grappa... 🌿continued in comments 🌿...